GABBR2 and KCTD12

Data Source:
BioGRID (pull down)

		GABBR2	KCTD12
Description		gamma-aminobutyric acid type B receptor subunit 2	potassium channel tetramerization domain containing 12
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Postsynaptic Membrane GABA Receptor Complex	Presynaptic Membrane Cell Projection Postsynaptic Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding Protein Heterodimerization Activity	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Neuron-glial Cell Signaling	Protein Homooligomerization
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Baclofen gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil
Diseases
GWAS		Gynecologic disease (multivariate analysis) ( 31488892) High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectories ( 27980656)	Incident chronic kidney disease ( 30955190) Response to fenofibrate (triglyceride levels) ( 27002377) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		11 interacting genes: ATF4 ATF5 DRD2 GABBR1 GLP1R HTR1A KCTD12 KCTD16 NSF SH3GL3 TAMALIN	3 interacting genes: ARAP1 GABBR2 ZNF792
Entrez ID		9568	115207
HPRD ID		09552	11060
Ensembl ID		ENSG00000136928	ENSG00000178695
Uniprot IDs		H9NIL8 O75899	A0A140VJM4 Q96CX2
PDB IDs		4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP 6UO8 6UO9 6UOA 6VJM 6W2X 6WIV 7C7Q 7C7S	6M8S 6QZL
Enriched GO Terms of Interacting Partners?
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