SEC22B and CERS6

Data Source:
BioGRID (two hybrid)

		SEC22B	CERS6
Description		SEC22 homolog B, vesicle trafficking protein	ceramide synthase 6
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Synaptic Vesicle ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Transport Vesicle COPI-coated Vesicle Phagocytic Vesicle Membrane SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	SNAP Receptor Activity Protein Binding Syntaxin Binding	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Positive Regulation Of Protein Catabolic Process COPII Vesicle Coating Vesicle Fusion With Golgi Apparatus Negative Regulation Of Autophagosome Assembly Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane	Inflammatory Response Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process
Pathways		ER-Phagosome pathway COPII-mediated vesicle transport Cargo concentration in the ER COPI-dependent Golgi-to-ER retrograde traffic	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Iris color (L* coordinate) ( 30895295)	Bipolar disorder ( 31043756) Parkinson's disease ( 27182965) Red cell distribution width ( 32888494 27863252 28957414) Skin aging (microtopography measurement) ( 28502801) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)
Interacting Genes		56 interacting genes: ABHD16A AIG1 AQP6 B3GAT3 CD79A CERS6 CLDN7 CLRN1 CPLX4 CREB3 CREB3L1 DPM3 EBP ELOVL4 ERGIC3 FAM174A FAM209A FCER1G FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPX8 HIBADH HSD17B11 HSD17B13 IFNGR2 JAGN1 KIR2DL3 LHFPL1 LHFPL5 LMNA MFF MFSD5 MGST2 MGST3 MMGT1 MRPS18B NDUFAF2 REEP4 RELL2 RHBDD1 SERINC2 SLC35C2 STX1A STX2 STX4 STX5 TLCD4 TM4SF19 TMEM139 TMEM167B TMEM229B TMEM86B	3 interacting genes: AGTR1 OPRL1 SEC22B
Entrez ID		9554	253782
HPRD ID		04939	17258
Ensembl ID		ENSG00000265808	ENSG00000172292
Uniprot IDs		O75396	Q6ZMG9
PDB IDs		2NUP 2NUT 3EGD 3EGX
Enriched GO Terms of Interacting Partners?
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