CERS6 and SEC22B

Data Source:
BioGRID (two hybrid)

		CERS6	SEC22B
Description		ceramide synthase 6	SEC22 homolog B, vesicle trafficking protein
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Golgi Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Synaptic Vesicle ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Transport Vesicle COPI-coated Vesicle Phagocytic Vesicle Membrane SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome
	Molecular Function	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity	SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Inflammatory Response Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Positive Regulation Of Protein Catabolic Process COPII Vesicle Coating Vesicle Fusion With Golgi Apparatus Negative Regulation Of Autophagosome Assembly Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Pathways		Sphingolipid de novo biosynthesis	ER-Phagosome pathway COPII-mediated vesicle transport Cargo concentration in the ER COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Parkinson's disease ( 27182965) Red cell distribution width ( 32888494 27863252 28957414) Skin aging (microtopography measurement) ( 28502801) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)	Iris color (L* coordinate) ( 30895295)
Interacting Genes		3 interacting genes: AGTR1 OPRL1 SEC22B	56 interacting genes: ABHD16A AIG1 AQP6 B3GAT3 CD79A CERS6 CLDN7 CLRN1 CPLX4 CREB3 CREB3L1 DPM3 EBP ELOVL4 ERGIC3 FAM174A FAM209A FCER1G FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPX8 HIBADH HSD17B11 HSD17B13 IFNGR2 JAGN1 KIR2DL3 LHFPL1 LHFPL5 LMNA MFF MFSD5 MGST2 MGST3 MMGT1 MRPS18B NDUFAF2 REEP4 RELL2 RHBDD1 SERINC2 SLC35C2 STX1A STX2 STX4 STX5 TLCD4 TM4SF19 TMEM139 TMEM167B TMEM229B TMEM86B
Entrez ID		253782	9554
HPRD ID		17258	04939
Ensembl ID		ENSG00000172292	ENSG00000265808
Uniprot IDs		Q6ZMG9	O75396
PDB IDs			2NUP 2NUT 3EGD 3EGX
Enriched GO Terms of Interacting Partners?
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