PMPCB and FXN

Data Source:
HPRD (two hybrid, in vitro)

		PMPCB	FXN
Description		peptidase, mitochondrial processing subunit beta	frataxin
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Processing Peptidase Complex	Mitochondrion Mitochondrial Matrix Cytosol L-cysteine Desulfurase Complex
	Molecular Function	Metalloendopeptidase Activity Metal Ion Binding	Ferroxidase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Iron Chaperone Activity 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Calcium Ion Transmembrane Transport	Oxidative Phosphorylation Heme Biosynthetic Process Ion Transport Cellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Positive Regulation Of Cell Population Proliferation Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Regulation Of Ferrochelatase Activity Iron-sulfur Cluster Assembly Protein Autoprocessing Iron Incorporation Into Metallo-sulfur Cluster Proprioception Positive Regulation Of Cell Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Negative Regulation Of Organ Growth Positive Regulation Of Lyase Activity Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Succinate Dehydrogenase Activity Positive Regulation Of Aconitate Hydratase Activity
Pathways		Mitochondrial protein import Processing of SMDT1	Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis
Drugs			Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases			Friedreich ataxia
GWAS		Diverticular disease ( 30177863)	Headache ( 29397368) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Seasonality ( 25562672)
Interacting Genes		5 interacting genes: FXN MARK3 NPSR1 PMPCA PTGER4	6 interacting genes: ACTN1 DAPP1 GOLGA6L9 PICK1 PMPCB RNF126
Entrez ID		9512	2395
HPRD ID		07539	06013
Ensembl ID		ENSG00000105819	ENSG00000165060
Uniprot IDs		B3KM34 O75439 Q96CP5	A0A0S2Z3G4 Q16595
PDB IDs			1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X 5KZ5 6NZU
Enriched GO Terms of Interacting Partners?
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