ADAMTS1 and ACAN

Data Source:
HPRD (in vitro)

		ADAMTS1	ACAN
Description		ADAM metallopeptidase with thrombospondin type 1 motif 1	aggrecan
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GO Annotations	Cellular Component	Basement Membrane Extracellular Matrix Cytoplasmic Vesicle Collagen-containing Extracellular Matrix	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Protein Binding Heparin Binding Metallopeptidase Activity Zinc Ion Binding	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding
	Biological Process	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Extracellular Matrix Organization Heart Trabecula Formation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Keratan Sulfate Catabolic Process
Pathways		Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs			Ilomastat
Diseases			Spondyloepiphyseal dysplasia, Kimberley type Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis
GWAS		Alzheimer's disease (late onset) ( 30820047) Blood protein levels ( 28240269) Cerebrospinal fluid neurofilament light levels ( 31930058) Health literacy ( 31250787) Metabolite levels ( 23823483)	Age-related hearing impairment ( 27764096) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		7 interacting genes: A2M ACAN FURIN KRT40 KRTAP10-8 VCAN VEGFA	18 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF TNFAIP6 TNR
Entrez ID		9510	176
HPRD ID		05530	01123
Ensembl ID		ENSG00000154734	ENSG00000157766
Uniprot IDs		B2RB33 Q9UHI8	P16112
PDB IDs		2JIH 2V4B 3Q2G 3Q2H	4MD4
Enriched GO Terms of Interacting Partners?
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