ADAMTS1 and ADRA2B

Data Source:
BioGRID (pull down)

		ADAMTS1	ADRA2B
Description		ADAM metallopeptidase with thrombospondin type 1 motif 1	adrenoceptor alpha 2B
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GO Annotations	Cellular Component	Basement Membrane Extracellular Matrix Cytoplasmic Vesicle Collagen-containing Extracellular Matrix	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Intracellular Membrane-bounded Organelle
	Molecular Function	Metalloendopeptidase Activity Protein Binding Heparin Binding Metallopeptidase Activity Zinc Ion Binding	G Protein-coupled Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Epinephrine Binding
	Biological Process	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Extracellular Matrix Organization Heart Trabecula Formation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Activation Of MAPK Activity Regulation Of Vascular Associated Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Negative Regulation Of Norepinephrine Secretion Platelet Activation Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Receptor Transactivation Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Blood Pressure Positive Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways		Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor G alpha (i) signalling events G alpha (z) signalling events
Drugs			Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Etomidate Clozapine Norepinephrine Phenylpropanolamine Loxapine Prochlorperazine Prazosin Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Clonidine Lisuride Guanabenz Epinephrine Tizanidine Apomorphine Paroxetine Trimipramine Risperidone Tolazoline Fenoldopam Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Guanfacine Ergoloid mesylate Promethazine Carvedilol Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine Dextroamphetamine Metamfetamine Celiprolol Dronedarone Rotigotine OPC-28326 Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Esmirtazapine Xylometazoline Levonordefrin Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine Xylazine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Blood protein levels ( 28240269) Cerebrospinal fluid neurofilament light levels ( 31930058) Health literacy ( 31250787) Metabolite levels ( 23823483)	Monocyte percentage of white cells ( 32888494)
Interacting Genes		7 interacting genes: A2M ACAN FURIN KRT40 KRTAP10-8 VCAN VEGFA	8 interacting genes: EIF2B1 GGA1 GGA2 GGA3 GNAI2 PPP1R9B UCHL1 YWHAZ
Entrez ID		9510	151
HPRD ID		05530	00086
Ensembl ID		ENSG00000154734	ENSG00000274286
Uniprot IDs		B2RB33 Q9UHI8	P18089
PDB IDs		2JIH 2V4B 3Q2G 3Q2H	2CVA 6K41 6K42
Enriched GO Terms of Interacting Partners?
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