MYOT and PDLIM3

Data Source:
BioGRID (two hybrid)

		MYOT	PDLIM3
Description		myotilin	PDZ and LIM domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Actin Cytoskeleton Z Disc Axon Sarcolemma Neuronal Cell Body	Stress Fiber Cytosol Adherens Junction Z Disc Filamentous Actin
	Molecular Function	Actin Binding Protein Binding Axon Guidance Receptor Activity Structural Constituent Of Muscle Alpha-actinin Binding	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Muscle Contraction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Synapse Organization	Heart Development Actin Cytoskeleton Organization Muscle Structure Development
Pathways
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Limb-girdle muscular dystrophy (LGMD)
GWAS		Atrial fibrillation ( 30061737) Heart rate ( 23583979) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		17 interacting genes: ACTN1 ACTN2 ACTN3 APP AXIN1 DOCK9 FLNA FLNC GPRASP2 LRP12 NME7 PDLIM3 PFDN5 ST7 TFG TRIM55 TRIM63	11 interacting genes: ABCA1 ACTN2 FHL1 MYOT MYOZ2 MYOZ3 MYPN PALLD RANBP2 RHOU RYR1
Entrez ID		9499	27295
HPRD ID		04981	08388
Ensembl ID		ENSG00000120729	ENSG00000154553
Uniprot IDs		A0A0C4DFM5 B4DT68 Q9UBF9	A0A087WYF8 A0A2U3TZH4 Q53GG5
PDB IDs		2KDG 2KKQ
Enriched GO Terms of Interacting Partners?
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