CABP1 and ITPR1

Data Source:
HPRD (in vitro, in vivo)

		CABP1	ITPR1
Description		calcium binding protein 1	inositol 1,4,5-trisphosphate receptor type 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Perinuclear Region Of Cytoplasm	Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse
	Molecular Function	Enzyme Inhibitor Activity Calcium Ion Binding Protein Binding Nuclear Localization Sequence Binding Calcium-dependent Protein Binding	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium-release Channel Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels
	Biological Process	Visual Perception Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Catalytic Activity Response To Stimulus	Response To Hypoxia Calcium Ion Transport Signal Transduction Post-embryonic Development Regulation Of Autophagy Platelet Activation Endoplasmic Reticulum Calcium Ion Homeostasis Epithelial Fluid Transport Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction
Pathways			PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway cGMP effects Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Caffeine 1D-myo-inositol 1,4,5-trisphosphate Glycerin
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronotype ( 30696823) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 33536424)	Airflow obstruction ( 22837378) Breast cancer ( 23535729) Calcium levels ( 29403010) Diabetic kidney disease ( 26305897) Gamma glutamyl transferase levels ( 29403010) Hand grip strength ( 29691431) Hematocrit ( 32888494) Lead levels ( 26025379) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Systolic blood pressure ( 26969751) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels ( 32203549 32154731) Uterine fibroids ( 30194396) Weight ( 28552196) Western dietary pattern ( 28644415)
Interacting Genes		9 interacting genes: CACNA1A CACNA1C CSNK2A2 FOS GRK5 ITPR1 ITPR3 NMT1 PPP3R1	32 interacting genes: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 BECN1 BRCA1 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERBB2 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 IRAG1 ITPR3 ITPRIP LYN PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4
Entrez ID		9478	3708
HPRD ID		12025	00925
Ensembl ID		ENSG00000157782	ENSG00000150995
Uniprot IDs		Q9NZU7	A0A3B3ITU8 A0A3F2YNW8 B4DER3 B4DGH1 Q14643 Q59H91
PDB IDs		2K7B 2K7C 2K7D 2LAN 2LAP 3OX5 3OX6
Enriched GO Terms of Interacting Partners?
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