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IL27RA and CLDN2
Data Source:
BioGRID
(two hybrid)
IL27RA
CLDN2
Description
interleukin 27 receptor subunit alpha
claudin 2
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Interleukin-12 Receptor Complex
Receptor Complex
Interleukin-23 Receptor Complex
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Integral Component Of Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Cytokine Receptor Activity
Interleukin-12 Receptor Binding
Protein Binding
Cytokine Binding
Interleukin-23 Binding
Interleukin-27 Receptor Activity
Structural Molecule Activity
Protein Binding
Identical Protein Binding
Biological Process
Positive Regulation Of T-helper 1 Type Immune Response
Negative Regulation Of Type 2 Immune Response
Immune Response
Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Negative Regulation Of Interleukin-17 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Isotype Switching To IgG Isotypes
Defense Response To Gram-positive Bacterium
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Negative Regulation Of T-helper 17 Type Immune Response
Negative Regulation Of T Cell Extravasation
Cell Adhesion
Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
Bicellular Tight Junction Assembly
Pathways
Interleukin-35 Signalling
Interleukin-27 signaling
Interleukin-27 signaling
Tight junction interactions
Drugs
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Immune response to measles-mumps-rubella vaccine (
24811271
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Alcoholic chronic pancreatitis (
28754779
)
Pancreatitis (
23143602
)
Interacting Genes
12 interacting genes:
BRICD5
CLDN2
DEFB121
DERL3
EBI3
GALNT15
IL27
MAPK8
MFSD5
SLC41A2
STAT1
YIPF6
29 interacting genes:
ADAM33
BTN3A2
CLEC2D
CSGALNACT2
CXCL9
CYSRT1
EMP3
FAM209A
GRM2
IGFBP5
IL27RA
KRT31
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP4-12
LAT
LNX1
LPAR3
MTDH
NOTCH2NLA
PIAS2
PLP1
TEX264
TJP1
TJP2
TMEM218
UBE2I
WNK4
Entrez ID
9466
9075
HPRD ID
09247
06471
Ensembl ID
ENSG00000104998
ENSG00000165376
Uniprot IDs
Q6UWB1
P57739
PDB IDs
4YYX
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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