IL27RA and BRICD5

Data Source:
BioGRID (two hybrid)

		IL27RA	BRICD5
Description		interleukin 27 receptor subunit alpha	BRICHOS domain containing 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex	Extracellular Space Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-27 Receptor Activity	Protein Binding
	Biological Process	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Activated T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation	Regulation Of Cell Population Proliferation
Pathways		Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		12 interacting genes: BRICD5 CLDN2 DEFB121 DERL3 EBI3 GALNT15 IL27 MAPK8 MFSD5 SLC41A2 STAT1 YIPF6	41 interacting genes: AQP6 ARL13B BIK CD69 CD79A CLEC2D CLRN1 CREB3L1 FKBP7 HHLA2 HSD17B13 ICAM3 IFNGR2 IFNLR1 IL27RA KIR2DL3 KLRC1 LMNA LRRC25 LRRC4C MRM1 MTIF3 MUC1 NEMP1 PLEKHO1 PSCA PVR SCN3B SGCB SGPL1 SIGLEC9 SLAMF6 SLC18A1 SLC18A2 SORT1 SYNE4 TMEM234 TMEM248 TMEM79 TMPRSS2 TMX2
Entrez ID		9466	283870
HPRD ID		09247	14482
Ensembl ID		ENSG00000104998	ENSG00000182685
Uniprot IDs		Q6UWB1	Q6PL45
PDB IDs
Enriched GO Terms of Interacting Partners?
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