TNFSF8 and ANG

Data Source:
HPRD (in vitro)

		TNFSF8	ANG
Description		TNF superfamily member 8	angiogenin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Basement Membrane Extracellular Space Nucleus Chromosome Nucleolus Actin Cytoskeleton Growth Cone Cytoplasmic Vesicle Angiogenin-PRI Complex Neuronal Cell Body
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	DNA Binding Actin Binding Endonuclease Activity Ribonuclease Activity Signaling Receptor Binding Copper Ion Binding Protein Binding Heparin Binding RRNA Binding Peptide Binding Protein Homodimerization Activity
	Biological Process	Immune Response Cell-cell Signaling Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Placenta Development Positive Regulation Of Endothelial Cell Proliferation Diacylglycerol Biosynthetic Process Cell Communication Activation Of Phospholipase C Activity RRNA Transcription Response To Hormone Cell Migration Negative Regulation Of Translation Antibacterial Humoral Response Actin Filament Polymerization Activation Of Protein Kinase B Activity Activation Of Phospholipase A2 Activity Adherens Junction Organization Positive Regulation Of Phosphorylation Homeostatic Process Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide RNA Phosphodiester Bond Hydrolysis
Pathways		TNFs bind their physiological receptors	Adherens junctions interactions
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 30500874 21102463 23266558) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgA levels ( 28628107) Inflammatory bowel disease ( 27569725 23128233) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 28425483 30643196) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 21297633)	Blood protein levels ( 30072576 28240269)
Interacting Genes		4 interacting genes: ANG BMP10 CXCL9 TNFRSF8	8 interacting genes: ABCG8 ACTC1 ACTN2 ATP6AP1 PTEN RNH1 TDGF1 TNFSF8
Entrez ID		944	283
HPRD ID		04852	00105
Ensembl ID		ENSG00000106952	ENSG00000214274
Uniprot IDs		A0A087X228 P32971 Q52M88	P03950 W0UV28
PDB IDs			1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36 5EOP 5EPZ 5EQO 5M9A 5M9C 5M9G 5M9J 5M9M 5M9P 5M9Q 5M9R 5M9S 5M9T 5M9V
Enriched GO Terms of Interacting Partners?
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