ANG and RNH1

Data Source:
HPRD (in vitro)

		ANG	RNH1
Description		angiogenin	ribonuclease/angiogenin inhibitor 1
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Nucleus Chromosome Nucleolus Actin Cytoskeleton Growth Cone Cytoplasmic Vesicle Angiogenin-PRI Complex Neuronal Cell Body	Nucleoplasm Cytosol Angiogenin-PRI Complex Extracellular Exosome
	Molecular Function	DNA Binding Actin Binding Endonuclease Activity Ribonuclease Activity Signaling Receptor Binding Copper Ion Binding Protein Binding Heparin Binding RRNA Binding Peptide Binding Protein Homodimerization Activity	Protein Binding Ribonuclease Inhibitor Activity
	Biological Process	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Placenta Development Positive Regulation Of Endothelial Cell Proliferation Diacylglycerol Biosynthetic Process Cell Communication Activation Of Phospholipase C Activity RRNA Transcription Response To Hormone Cell Migration Negative Regulation Of Translation Antibacterial Humoral Response Actin Filament Polymerization Activation Of Protein Kinase B Activity Activation Of Phospholipase A2 Activity Adherens Junction Organization Positive Regulation Of Phosphorylation Homeostatic Process Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide RNA Phosphodiester Bond Hydrolysis	MRNA Catabolic Process Negative Regulation Of Catalytic Activity Regulation Of Angiogenesis
Pathways		Adherens junctions interactions
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Blood protein levels ( 30072576 28240269)	Body mass index ( 25673413) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)
Interacting Genes		8 interacting genes: ABCG8 ACTC1 ACTN2 ATP6AP1 PTEN RNH1 TDGF1 TNFSF8	3 interacting genes: ANG RNASE1 SDCBP
Entrez ID		283	6050
HPRD ID		00105	01412
Ensembl ID		ENSG00000214274	ENSG00000023191
Uniprot IDs		P03950 W0UV28	A0A140VJT8 P13489
PDB IDs		1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36 5EOP 5EPZ 5EQO 5M9A 5M9C 5M9G 5M9J 5M9M 5M9P 5M9Q 5M9R 5M9S 5M9T 5M9V	1A4Y 1Z7X 2BEX 2Q4G
Enriched GO Terms of Interacting Partners?
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