TMPRSS11D and ACE2

Data Source:
BioGRID (enzymatic study)

		TMPRSS11D	ACE2
Description		transmembrane serine protease 11D	angiotensin converting enzyme 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	Virus Receptor Activity Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding
	Biological Process	Proteolysis Respiratory Gaseous Exchange By Respiratory System	Regulation Of Cytokine Production Angiotensin Maturation Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Tryptophan Transport Regulation Of Vasoconstriction Regulation Of Transmembrane Transporter Activity Regulation Of Cell Population Proliferation Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Regulation Of Inflammatory Response Positive Regulation Of Amino Acid Transport Positive Regulation Of Cardiac Muscle Contraction Blood Vessel Diameter Maintenance Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Positive Regulation Of L-proline Import Across Plasma Membrane Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Metabolism of Angiotensinogen to Angiotensins Attachment and Entry Potential therapeutics for SARS Attachment and Entry Attachment and Entry
Drugs			Chloroquine Hydroxychloroquine SPP1148 N-(2-Aminoethyl)-1-aziridineethanamine
Diseases
GWAS		Metabolite levels ( 23823483) Regular attendance at a pub or social club ( 29970889) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		2 interacting genes: ACE2 SGTA	12 interacting genes: AGT CALM1 DEFA5 DLEU2 GHRL NTS PDZK1 SHANK1 SLC6A19 SNX17 TMPRSS11A TMPRSS11D
Entrez ID		9407	59272
HPRD ID		05642	02274
Ensembl ID		ENSG00000153802	ENSG00000130234
Uniprot IDs		B4DL57 O60235	Q9BYF1
PDB IDs			1R42 1R4L 1XJP 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL 6ACG 6ACJ 6ACK 6CS2 6LZG 6M0J 6M17 6M18 6M1D 6VW1 7A91 7A92 7A94 7A95 7A96 7A97 7A98
Enriched GO Terms of Interacting Partners?
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