ACE2 and SLC6A19

Data Source:
BioGRID (x-ray crystallography, pull down, x-ray crystallography, biochemical)

		ACE2	SLC6A19
Description		angiotensin converting enzyme 2	solute carrier family 6 member 19
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Membrane Raft Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Virus Receptor Activity Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding	Protein Binding Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity Symporter Activity
	Biological Process	Regulation Of Cytokine Production Angiotensin Maturation Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Tryptophan Transport Regulation Of Vasoconstriction Regulation Of Transmembrane Transporter Activity Regulation Of Cell Population Proliferation Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Regulation Of Inflammatory Response Positive Regulation Of Amino Acid Transport Positive Regulation Of Cardiac Muscle Contraction Blood Vessel Diameter Maintenance Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Positive Regulation Of L-proline Import Across Plasma Membrane Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process	Amino Acid Transmembrane Transport Amino Acid Transport Response To Nutrient Neutral Amino Acid Transport Sodium Ion Transmembrane Transport
Pathways		Metabolism of Angiotensinogen to Angiotensins Attachment and Entry Potential therapeutics for SARS Attachment and Entry Attachment and Entry	Amino acid transport across the plasma membrane Na+/Cl- dependent neurotransmitter transporters Defective SLC6A19 causes Hartnup disorder (HND) Defective SLC6A19 causes Hartnup disorder (HND)
Drugs		Chloroquine Hydroxychloroquine SPP1148 N-(2-Aminoethyl)-1-aziridineethanamine
Diseases			Hartnup disorder Iminoglycinuria
GWAS			Pancreatic cancer ( 25086665) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407) Urine 6-bromotryptophan levels in chronic kidney disease ( 32572055)
Interacting Genes		12 interacting genes: AGT CALM1 DEFA5 DLEU2 GHRL NTS PDZK1 SHANK1 SLC6A19 SNX17 TMPRSS11A TMPRSS11D	1 interacting genes: ACE2
Entrez ID		59272	340024
HPRD ID		02274	10596
Ensembl ID		ENSG00000130234	ENSG00000174358
Uniprot IDs		Q9BYF1	Q695T7
PDB IDs		1R42 1R4L 1XJP 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL 6ACG 6ACJ 6ACK 6CS2 6LZG 6M0J 6M17 6M18 6M1D 6VW1 7A91 7A92 7A94 7A95 7A96 7A97 7A98	6M17 6M18 6M1D
Enriched GO Terms of Interacting Partners?
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