LIPG and FANCA

Data Source:
BioGRID (two hybrid)

		LIPG	FANCA
Description		lipase G, endothelial type	FA complementation group A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Golgi Apparatus Cell Surface	Nucleus Nucleoplasm Cytoplasm Fanconi Anaemia Nuclear Complex
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Heparin Binding Phospholipase A1 Activity Lipase Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Biosynthetic Process Response To Nutrient Cell Population Proliferation Phospholipid Catabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Lipid Catabolic Process Triglyceride Catabolic Process Positive Regulation Of Cholesterol Transport High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis Reverse Cholesterol Transport Regulation Of Lipoprotein Metabolic Process Phospholipid Homeostasis	DNA Repair Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Cell Population Proliferation Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex Assembly Regulation Of CD40 Signaling Pathway
Pathways		HDL remodeling	Fanconi Anemia Pathway
Drugs
Diseases			Fanconi anemia
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Apolipoprotein A1 levels ( 32203549 29084231) Blood metabolite levels ( 24816252) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol ester levels in very large HDL ( 29084231) Cholesterol, total ( 24097068 19060911 25961943 20686565) Coronary artery disease ( 29212778) Free cholesterol levels in medium HDL ( 29084231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 24097068 20031538 31170924 28270201 24507774 18193043 18193044 20864672 19060906 19060911 30275531 25961943 20686565 26582766) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29403010 31217584) Large HDL particle concentration ( 29084231) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219 19936222) Low density lipoprotein cholesterol levels ( 32154731) Mean diameter of HDL particles ( 29084231) Mean spheric corpuscular volume ( 32888494) Medium HDL particle concentration ( 29084231) Metabolic syndrome ( 31589552) Metabolite levels (lipoprotein measures) ( 27005778) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors in depression ( 27622933) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Testicular germ cell tumor ( 23666239) Total cholesterol levels ( 28334899 29403010 30275531) Total cholesterol levels in HDL ( 29084231) Total cholesterol levels in large HDL ( 29084231)	Brain morphology (MOSTest) ( 32665545) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 31959993 30054594) Low tan response ( 29739929) Monocyte percentage of white cells ( 32888494) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)
Interacting Genes		2 interacting genes: EXOSC5 FANCA	48 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 HSP90AA1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24
Entrez ID		9388	2175
HPRD ID		04730	06186
Ensembl ID		ENSG00000101670	ENSG00000187741
Uniprot IDs		A0A024R2B5 B4DTR8 Q9Y5X9	O15360
PDB IDs
Enriched GO Terms of Interacting Partners?
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