FANCA and MKNK1

Data Source:
BioGRID (two hybrid)

		FANCA	MKNK1
Description		FA complementation group A	MAPK interacting serine/threonine kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Fanconi Anaemia Nuclear Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	DNA Repair Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Cell Population Proliferation Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex Assembly Regulation Of CD40 Signaling Pathway	Regulation Of Translation Protein Phosphorylation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation
Pathways		Fanconi Anemia Pathway	Spry regulation of FGF signaling
Drugs			Fostamatinib
Diseases		Fanconi anemia
GWAS		Brain morphology (MOSTest) ( 32665545) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 31959993 30054594) Low tan response ( 29739929) Monocyte percentage of white cells ( 32888494) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)	Schizophrenia ( 26198764) Triglyceride levels ( 31170924)
Interacting Genes		48 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 HSP90AA1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24	26 interacting genes: APP ATXN3 CREBBP CREM DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1
Entrez ID		2175	8569
HPRD ID		06186	09468
Ensembl ID		ENSG00000187741	ENSG00000079277
Uniprot IDs		O15360	A8K341 Q7Z319 Q9BUB5
PDB IDs			2HW6 2Y9Q 5WVD
Enriched GO Terms of Interacting Partners?
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