NRXN1 and SYTL2

Data Source:
HPRD (in vitro)

		NRXN1	SYTL2
Description		neurexin 1	synaptotagmin like 2
Image
GO Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Nuclear Membrane Vesicle Presynaptic Membrane Cell Projection Neuronal Cell Body	Cytoplasm Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Melanosome Exocytic Vesicle
	Molecular Function	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Signaling Receptor Activity Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatase Binding Neurexin Family Protein Binding
	Biological Process	Neuron Cell-cell Adhesion Chemical Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Adult Behavior Social Behavior Vocal Learning Neuromuscular Process Controlling Balance Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Vocalization Behavior Positive Regulation Of Synapse Maturation Postsynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Positive Regulation Of Excitatory Postsynaptic Potential	Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Negative Regulation Of Phosphatase Activity Vesicle-mediated Transport
Pathways		Neurexins and neuroligins Neurexins and neuroligins Non-integrin membrane-ECM interactions Neurexins and neuroligins Neurexins and neuroligins
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Adult body size ( 32376654) Body mass index ( 28892062) Chromosomal aberration frequency (chromatid type) ( 31586183) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Educational attainment ( 25201988) General risk tolerance (MTAG) ( 30643258) Isovolumetric relaxation time ( 28394258) Lateral ventricle temporal horn volume ( 31530798) Longevity ( 20834067) Lung cancer in ever smokers ( 28604730) Metabolite levels (HVA/MHPG ratio) ( 23319000) Morning person ( 30696823) Nicotine dependence symptom count ( 25555482) Personality dimensions ( 20691247) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive astigmatism ( 25367360) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Severe gingival inflammation ( 28459102) Systolic blood pressure ( 30224653 30578418) Temperament ( 22832960) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Triglyceride levels ( 32203549) Word spelling ( 30741946)	Pallidum volume ( 31530798) Refractive error ( 32231278)
Interacting Genes		28 interacting genes: AFDN APBA1 APBA2 ATP13A2 CASK MACF1 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3	9 interacting genes: FBXO25 LNX1 MORN4 MTERF1 NRXN1 PPP1CA RAB27A RAB27B YIF1A
Entrez ID		9378	54843
HPRD ID		11858	10260
Ensembl ID		ENSG00000179915	ENSG00000137501
Uniprot IDs		A0A0D9SEM5 A0A0D9SEQ7 A0A1D5RMU6 E7EQN4 E7ERL8 H0Y568 H7BYC7 P58400 Q9ULB1	A0A0U1RR07 Q9HCH5
PDB IDs		3B3Q 5Z8Y 6NID	3BC1
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?