KIF3B and RAB4A

Data Source:
HPRD (in vivo, in vitro)

		KIF3B	RAB4A
Description		kinesin family member 3B	RAB4A, member RAS oncogene family
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GO Annotations	Cellular Component	Centrosome Cytosol Kinesin Complex Plus-end Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Membrane Kinesin II Complex Midbody Extracellular Exosome Ciliary Tip Axon Cytoplasm	Endosome Cytosol Plasma Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Postsynaptic Recycling Endosome Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Small GTPase Binding Intraciliary Transport Particle B Binding	ATPase Activator Activity GTPase Activity Protein Binding GTP Binding GDP Binding Syntaxin Binding Ionotropic Glutamate Receptor Binding ATPase Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Mitotic Spindle Organization Mitotic Centrosome Separation Determination Of Left/right Symmetry Anterograde Axonal Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Intraciliary Transport Involved In Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Mitotic Spindle Assembly	Phosphatidylinositol Biosynthetic Process Protein Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Positive Regulation Of ATPase Activity
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins	Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Monocyte percentage of white cells ( 27863252)	Aging ( 22773346) Leukoderma in response to rhododendrol ( 32558222) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)
Interacting Genes		12 interacting genes: APP IFT20 KIF3A KIFAP3 LMO2 LMO4 MAP3K10 MAP3K11 NEDD4L PRC1 RAB4A SASH1	33 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 FAM71C GDI2 GRIPAP1 HACE1 IDH3A KCTD7 KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABEP2 RABGAP1 RABGEF1 RBSN RUFY1 SOD2 STX4 TP53 VPS52 ZNF830
Entrez ID		9371	5867
HPRD ID		04781	01541
Ensembl ID		ENSG00000101350	ENSG00000168118
Uniprot IDs		O15066	A0A024R3U9 A0A087WYT5 P20338
PDB IDs		3B6U	1YU9 1Z0K 2BMD 2BME
Enriched GO Terms of Interacting Partners?
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