LONP1 and CYP2C8

Data Source:
BioGRID (two hybrid)

		LONP1	CYP2C8
Description		lon peptidase 1, mitochondrial	cytochrome P450 family 2 subfamily C member 8
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Mitochondrial Nucleoid	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Mitochondrial Promoter Sequence-specific DNA Binding Single-stranded DNA Binding Single-stranded RNA Binding ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding ATP Binding ATPase Activity Identical Protein Binding ADP Binding Sequence-specific DNA Binding G-quadruplex DNA Binding DNA Polymerase Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Caffeine Oxidase Activity Aromatase Activity Estrogen 16-alpha-hydroxylase Activity
	Biological Process	Mitochondrial Genome Maintenance Response To Hypoxia Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Mitochondrion Organization Aging Response To Hormone Response To Aluminum Ion Mitochondrial DNA Metabolic Process Cellular Response To Oxidative Stress Chaperone-mediated Protein Complex Assembly Proteolysis Involved In Cellular Protein Catabolic Process Oxidation-dependent Protein Catabolic Process	Lipid Hydroxylation Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Retinol Metabolic Process Retinoic Acid Metabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Oxidative Demethylation Omega-hydroxylase P450 Pathway
Pathways			Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs
Drugs			Isoniazid Palmitic Acid (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)	Blood metabolite levels ( 24816252) Gout ( 22179738) Immune response to smallpox vaccine (IL-6) ( 22542470) Osteonecrosis of the jaw ( 18594024) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Response to clopidogrel therapy ( 19706858) Tuberculosis ( 24057671) Urinary metabolite levels in chronic kidney disease ( 31959995) Warfarin maintenance dose ( 23755828)
Interacting Genes		11 interacting genes: A2M APOE CDC37 CDC42 CYP2C8 ECSIT IFIT3 IFIT5 LOXL4 MAST1 RNF32	12 interacting genes: A2M APOE BLMH DNAJB1 ECSIT EXOC6 IFIT3 LONP1 MAST1 PSEN1 RIN3 RNF32
Entrez ID		9361	1558
HPRD ID		05689	03083
Ensembl ID		ENSG00000196365	ENSG00000138115
Uniprot IDs		P36776	B7Z1F5 P10632
PDB IDs		2X36	1PQ2 2NNH 2NNI 2NNJ 2VN0
Enriched GO Terms of Interacting Partners?
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