UBE4A and PTTG1

Data Source:
BioGRID (enzymatic study)

		UBE4A	PTTG1
Description		ubiquitination factor E4A	PTTG1 regulator of sister chromatid separation, securin
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway	DNA Repair Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Catabolic Process Homologous Chromosome Segregation Chromosome Organization Cell Division Negative Regulation Of Mitotic Sister Chromatid Separation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)	Dermatomyositis or juvenile dermatomyositis ( 26362759) Insulin-related traits ( 22791750) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 21408207 28714469 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		13 interacting genes: CASP6 EPHA2 GZMB IP6K1 MAVS PTTG1 RSAD2 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP	23 interacting genes: ANAPC11 ANAPC2 AURKA CAMK2A CDC20 CDC27 CDC34 CDK1 CRK CUL1 DNAJA1 FZR1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2C UBE2N UBE4A XRCC6
Entrez ID		9354	9232
HPRD ID		06793	04998
Ensembl ID		ENSG00000110344	ENSG00000164611
Uniprot IDs		Q14139	O95997 Q6IAL9
PDB IDs		1WGM
Enriched GO Terms of Interacting Partners?
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