TAOK2 and MAPRE3

Data Source:
BioGRID (two hybrid)

		TAOK2	MAPRE3
Description		TAO kinase 2	microtubule associated protein RP/EB family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Actin Cytoskeleton Integral Component Of Membrane Axon Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Receptor Complex Dendritic Growth Cone Axonal Growth Cone	Cytoplasm Microtubule Organizing Center Midbody Microtubule Plus-end Spindle Midzone Mitotic Spindle Astral Microtubule End
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Neuropilin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Microtubule Binding Protein C-terminus Binding Protein Kinase Binding Identical Protein Binding Microtubule Plus-end Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Regulation Of Cell Growth Protein Targeting To Membrane Apoptotic Process Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Axonogenesis Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Actin Cytoskeleton Organization Positive Regulation Of JNK Cascade Protein Autophosphorylation Focal Adhesion Assembly Neuron Projection Morphogenesis Stress-activated MAPK Cascade Basal Dendrite Morphogenesis Basal Dendrite Arborization	Protein Localization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Spindle Assembly Cell Division Positive Regulation Of Microtubule Plus-end Binding Protein Localization To Microtubule Plus-end
Pathways
Drugs		Dexfosfoserine Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Metabolic syndrome ( 31589552) Schizophrenia ( 28991256 25056061 29483656 30285260) Triglyceride levels ( 32203549 32154731) Waist circumference ( 31928498)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate in non-diabetics ( 31451708) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: CIDEB ELK1 KLHL12 KRTAP6-3 MAP2K3 MAP2K6 MAPRE3 MEGF10 RCHY1 TUBA1A TUBA4A TUBB USF1	60 interacting genes: ANKRD1 APC2 AURKA AURKB C20orf202 C4orf45 CCSER1 CHRDL2 CLASP1 CRTAC1 DCTN2 DDIT4L DOK4 EIF4E2 FAM161B FOXD4L1 FOXD4L4 FXR2 GAS2L2 GTF2F2 GTSE1 HROB IKZF1 JUN KIF19 KLHDC7B KNSTRN LAP3 LHX4 LMO2 MAPRE1 MAPRE2 MARCHF7 MEOX2 MRPL12 PDE4DIP PICK1 POU4F1 PSMA1 PSMB1 PSRC1 RAB1A REL SDCBP SIAH1 SLAIN1 SPDYE2 SPDYE2B TAOK2 TEX43 TLE5 TRAIP TRIM14 TROAP TXN2 YAF2 ZC2HC1A ZC2HC1C ZNF526 ZNF547
Entrez ID		9344	22924
HPRD ID		18147	16156
Ensembl ID		ENSG00000149930	ENSG00000084764
Uniprot IDs		Q9UL54	Q9UPY8
PDB IDs			1WYO 3CO1 3JAK 3JAL 3JAR 3TQ7
Enriched GO Terms of Interacting Partners?
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