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KLF4 and GYS1
Data Source:
BioGRID
(two hybrid)
KLF4
GYS1
Description
Kruppel like factor 4
glycogen synthase 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytoplasm
Cytosol
Membrane
Inclusion Body
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity
RNA Polymerase II Transcription Factor Binding
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Phosphatidylinositol 3-kinase Regulator Activity
Histone Deacetylase Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Glycogen (starch) Synthase Activity
Protein Binding
Glucose Binding
Protein Kinase Binding
Glycogen Synthase Activity, Transferring Glucose-1-phosphate
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Mesodermal Cell Fate Determination
Negative Regulation Of Cell Population Proliferation
Epidermal Cell Differentiation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Muscle Hyperplasia
Negative Regulation Of Angiogenesis
Stem Cell Population Maintenance
Post-embryonic Camera-type Eye Development
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Interleukin-8 Production
Negative Regulation Of Heterotypic Cell-cell Adhesion
Somatic Stem Cell Population Maintenance
Post-embryonic Hemopoiesis
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Nitric Oxide Biosynthetic Process
Fat Cell Differentiation
Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hemoglobin Biosynthetic Process
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Axon Regeneration
Epidermis Morphogenesis
Negative Regulation Of Inflammatory Response
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Protein Kinase B Signaling
Positive Regulation Of Telomerase Activity
Canonical Wnt Signaling Pathway
Negative Regulation Of Response To Cytokine Stimulus
Cellular Response To Hydrogen Peroxide
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Cellular Response To Cycloheximide
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Blastocyst Development
Cellular Response To Peptide
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Core Promoter Binding
Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Glycogen Biosynthetic Process
Heart Development
Pathways
Transcriptional regulation of white adipocyte differentiation
Synthesis, secretion, and deacylation of Ghrelin
Transcriptional regulation of pluripotent stem cells
FOXO-mediated transcription of cell cycle genes
Glycogen synthesis
Myoclonic epilepsy of Lafora
Glycogen storage disease type XV (GYG1)
Glycogen storage disease type 0 (muscle GYS1)
Drugs
Diseases
Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS
Breast cancer (
21263130
)
Colorectal or endometrial cancer (
26621817
)
Coronary artery disease (
33020668
)
Cotinine glucuronidation (
25293881
)
Cutaneous malignant melanoma (
26237428
)
Glycated hemoglobin levels (
28898252
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Heel bone mineral density (
30598549
28869591
)
Prostate cancer (
23023329
)
Psoriasis (
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Takayasu arteritis (
25604533
)
Tenofovir clearance in HIV infection (
26148204
)
Interacting Genes
21 interacting genes:
APP
CREBBP
DVL3
ELK1
EP300
FBXO7
GYS1
HDAC1
HDAC5
HGS
HSF2BP
KAT5
KLF6
MYO15B
PAX9
PLK1
SETD7
SP1
TLE5
TP53
VHL
43 interacting genes:
AIMP2
APP
BEND7
CCDC33
CDCA8
CLVS2
CRX
CSNK2A1
EFHC2
FAM228A
GSK3B
GYG1
GYG2
HOXB6
HOXC8
IHO1
INCA1
KATNBL1
KLF1
KLF4
MAPKAPK5
MEOX1
NDUFB7
NHLRC1
PCYT1A
PINX1
PLAGL2
PNMA5
PRKACA
RBM48
SNIP1
SORBS3
SUMO2
TFAP2D
TLE5
WASHC1
ZBTB33
ZNF212
ZNF326
ZNF474
ZNF552
ZNF620
ZNF774
Entrez ID
9314
2997
HPRD ID
03769
00721
Ensembl ID
ENSG00000136826
ENSG00000104812
Uniprot IDs
O43474
P13807
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Intersection)
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