GYS1 and NHLRC1

Data Source:
BioGRID (pull down)

		GYS1	NHLRC1
Description		glycogen synthase 1	NHL repeat containing E3 ubiquitin protein ligase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Inclusion Body	Nucleus Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Glycogen (starch) Synthase Activity Protein Binding Glucose Binding Protein Kinase Binding Glycogen Synthase Activity, Transferring Glucose-1-phosphate	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Glycogen Biosynthetic Process Heart Development	Protein Polyubiquitination Glycogen Biosynthetic Process Autophagy Regulation Of Gene Expression Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Localization To Plasma Membrane
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage disease type XV (GYG1) Glycogen storage disease type 0 (muscle GYS1)	Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS			Intrinsic epigenetic age acceleration ( 29374233)
Interacting Genes		43 interacting genes: AIMP2 APP BEND7 CCDC33 CDCA8 CLVS2 CRX CSNK2A1 EFHC2 FAM228A GSK3B GYG1 GYG2 HOXB6 HOXC8 IHO1 INCA1 KATNBL1 KLF1 KLF4 MAPKAPK5 MEOX1 NDUFB7 NHLRC1 PCYT1A PINX1 PLAGL2 PNMA5 PRKACA RBM48 SNIP1 SORBS3 SUMO2 TFAP2D TLE5 WASHC1 ZBTB33 ZNF212 ZNF326 ZNF474 ZNF552 ZNF620 ZNF774	9 interacting genes: AGL EPM2A GYS1 NNAT PPP1R3C UBE2D1 UBE2D3 UBE2E1 UBE2H
Entrez ID		2997	378884
HPRD ID		00721	06995
Ensembl ID		ENSG00000104812	ENSG00000187566
Uniprot IDs		P13807	Q6VVB1
PDB IDs
Enriched GO Terms of Interacting Partners?
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