ASIC3 and ASIC2

Data Source:
HPRD (in vivo)

		ASIC3	ASIC2
Description		acid sensing ion channel subunit 3	acid sensing ion channel subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Dendritic Spine
	Molecular Function	Cation Channel Activity Sodium Channel Activity Ligand-gated Sodium Channel Activity Enterobactin Transmembrane Transporter Activity Acid-sensing Ion Channel Activity	Protein Binding Ligand-gated Sodium Channel Activity Ion Gated Channel Activity
	Biological Process	Signal Transduction Sensory Perception Response To Heat Response To Acidic PH Ion Transmembrane Transport Sodium Ion Transmembrane Transport Enterobactin Transport Sensory Perception Of Sour Taste Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain	Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Chemical Synaptic Transmission Central Nervous System Development Peripheral Nervous System Development Phototransduction Sensory Perception Of Sound Response To Acidic PH Regulation Of Vasoconstriction Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Protein Localization To Synapse Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Apoptotic Process Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Involved In Sensory Perception Positive Regulation Of Synapse Assembly Inorganic Cation Transmembrane Transport
Pathways		Stimuli-sensing channels	Stimuli-sensing channels
Drugs		Agmatine	Amiloride
Diseases
GWAS		Eyebrow thickness ( 26926045)	Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 26912274) Mosquito bite size ( 28199695) Plasma parathyroid hormone levels ( 30134803) Polycystic ovary syndrome ( 30343302) Serum bilirubin levels in metabolic syndrome ( 30621171) Severe gingival inflammation ( 28459102)
Interacting Genes		9 interacting genes: ASIC2 CSNK2A1 DLG4 GOPC LIN7B MAGI1 PATJ PRKACA STOM	4 interacting genes: ASIC1 ASIC3 PICK1 STOM
Entrez ID		9311	40
HPRD ID		10626	03471
Ensembl ID		ENSG00000213199	ENSG00000108684
Uniprot IDs		A0A090N7X8 A0A090N8Q1 A0A090N8Z6 Q9UHC3	Q16515
PDB IDs			6L6P
Enriched GO Terms of Interacting Partners?
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