ASIC2 and ASIC1

Data Source:
HPRD (in vitro, in vivo)

		ASIC2	ASIC1
Description		acid sensing ion channel subunit 2	acid sensing ion channel subunit 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Dendritic Spine	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Synapse
	Molecular Function	Protein Binding Ligand-gated Sodium Channel Activity Ion Gated Channel Activity	Protein Binding Ligand-gated Sodium Channel Activity Ion Gated Channel Activity Acid-sensing Ion Channel Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Chemical Synaptic Transmission Central Nervous System Development Peripheral Nervous System Development Phototransduction Sensory Perception Of Sound Response To Acidic PH Regulation Of Vasoconstriction Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Protein Localization To Synapse Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Apoptotic Process Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Involved In Sensory Perception Positive Regulation Of Synapse Assembly Inorganic Cation Transmembrane Transport	Behavioral Fear Response Response To Amphetamine Sodium Ion Transport Signal Transduction Memory Associative Learning Response To PH Response To Acidic PH Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Neurotransmitter Secretion Sensory Perception Of Sour Taste Protein Homotrimerization Calcium Ion Transmembrane Transport Cellular Response To PH
Pathways		Stimuli-sensing channels	Stimuli-sensing channels
Drugs		Amiloride	Amiloride
Diseases
GWAS		Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 26912274) Mosquito bite size ( 28199695) Plasma parathyroid hormone levels ( 30134803) Polycystic ovary syndrome ( 30343302) Serum bilirubin levels in metabolic syndrome ( 30621171) Severe gingival inflammation ( 28459102)
Interacting Genes		4 interacting genes: ASIC1 ASIC3 PICK1 STOM	7 interacting genes: ASIC2 ATXN3 KIR3DL3 MGST2 PICK1 PRKACA STOM
Entrez ID		40	41
HPRD ID		03471	04182
Ensembl ID		ENSG00000108684	ENSG00000110881
Uniprot IDs		Q16515	A8K1U5 P78348
PDB IDs		6L6P	6L6I 7CFS 7CFT
Enriched GO Terms of Interacting Partners?
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