ZNF276 and PFKFB1

Data Source:
BioGRID (two hybrid)

		ZNF276	PFKFB1
Description		zinc finger protein 276	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Chromosome	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
	Molecular Function	Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific Double-stranded DNA Binding	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Binding Identical Protein Binding Fructose-6-phosphate Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Dephosphorylation Animal Organ Regeneration Response To Insulin Positive Regulation Of Glucokinase Activity Response To Glucagon Response To Starvation Negative Regulation Of Glycolytic Process Positive Regulation Of Glycolytic Process Carbohydrate Phosphorylation Response To Glucocorticoid Response To CAMP
Pathways			PKA-mediated phosphorylation of key metabolic factors PP2A-mediated dephosphorylation of key metabolic factors Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs			D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate sn-glycerol 3-phosphate Adenosine 5'-[gamma-thio]triphosphate Guanosine-5'-Triphosphate Fructose-6-phosphate
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		13 interacting genes: AP1M1 ATXN1 CDC37 CIB3 FAM161A GCC1 MEOX2 MORF4L1 PFKFB1 PICK1 SEPHS1 TCEANC ZBTB8A	15 interacting genes: AKT1 APP DDIT4L KATNBL1 PDE4A PFKFB3 PFKFB4 PLEKHG4 PRKACA PRKCA VWC2 ZNF276 ZNF474 ZNF655 ZNF688
Entrez ID		92822	5207
HPRD ID		12235	02411
Ensembl ID		ENSG00000158805	ENSG00000158571
Uniprot IDs		A8K186 I6L9I3 Q8N554	I1Z9G4 P16118
PDB IDs			1K6M
Enriched GO Terms of Interacting Partners?
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