PFKFB1 and ZNF276

Data Source:
BioGRID (two hybrid)

		PFKFB1	ZNF276
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	zinc finger protein 276
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex	Kinetochore Condensed Chromosome Kinetochore Nucleus Chromosome
	Molecular Function	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Binding Identical Protein Binding Fructose-6-phosphate Binding	Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Dephosphorylation Animal Organ Regeneration Response To Insulin Positive Regulation Of Glucokinase Activity Response To Glucagon Response To Starvation Negative Regulation Of Glycolytic Process Positive Regulation Of Glycolytic Process Carbohydrate Phosphorylation Response To Glucocorticoid Response To CAMP	Regulation Of Transcription By RNA Polymerase II
Pathways		PKA-mediated phosphorylation of key metabolic factors PP2A-mediated dephosphorylation of key metabolic factors Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs		D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate sn-glycerol 3-phosphate Adenosine 5'-[gamma-thio]triphosphate Guanosine-5'-Triphosphate Fructose-6-phosphate
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Brain morphology (MOSTest) ( 32665545) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)
Interacting Genes		15 interacting genes: AKT1 APP DDIT4L KATNBL1 PDE4A PFKFB3 PFKFB4 PLEKHG4 PRKACA PRKCA VWC2 ZNF276 ZNF474 ZNF655 ZNF688	13 interacting genes: AP1M1 ATXN1 CDC37 CIB3 FAM161A GCC1 MEOX2 MORF4L1 PFKFB1 PICK1 SEPHS1 TCEANC ZBTB8A
Entrez ID		5207	92822
HPRD ID		02411	12235
Ensembl ID		ENSG00000158571	ENSG00000158805
Uniprot IDs		I1Z9G4 P16118	A8K186 I6L9I3 Q8N554
PDB IDs		1K6M
Enriched GO Terms of Interacting Partners?
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