ITGB1BP1 and DLD

Data Source:
BioGRID (two hybrid)

		ITGB1BP1	DLD
Description		integrin subunit beta 1 binding protein 1	dihydrolipoamide dehydrogenase
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Nuclear Body Lamellipodium Centriolar Satellite Perinuclear Region Of Cytoplasm Cell Periphery	Nucleus Mitochondrion Mitochondrial Matrix Motile Cilium Acrosomal Matrix Oxoglutarate Dehydrogenase Complex Pyruvate Dehydrogenase Complex
	Molecular Function	GDP-dissociation Inhibitor Activity Integrin Binding Protein Binding	Dihydrolipoyl Dehydrogenase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Lipoamide Binding Flavin Adenine Dinucleotide Binding NAD Binding
	Biological Process	Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell-matrix Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Fibroblast Migration Cell Migration Cell Differentiation Biomineral Tissue Development Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Integrin Activation Regulation Of Cell Adhesion Mediated By Integrin Tube Formation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of GTPase Activity Receptor Clustering Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Myoblast Migration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Targeting To Membrane Blood Vessel Diameter Maintenance Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Integrin-mediated Signaling Pathway	Pyruvate Metabolic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Mitochondrial Electron Transport, NADH To Ubiquinone Proteolysis Lysine Catabolic Process Gastrulation Aging Branched-chain Amino Acid Catabolic Process Lipoate Metabolic Process Regulation Of Membrane Potential Cell Redox Homeostasis Sperm Capacitation Dihydrolipoamide Metabolic Process Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate Histone Succinylation
Pathways			Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Glycine degradation Pyruvate metabolism Branched-chain amino acid catabolism Lysine catabolism Citric acid cycle (TCA cycle)
Drugs			NADH Flavin adenine dinucleotide
Diseases			Maple syrup urine disease (MSUD) Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS			Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908 23128233 20228799 19122664) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		19 interacting genes: APP CAMK2A CCDC33 DLD EEF1A1 FAF1 FIGNL1 GSDME ITGB1 KRIT1 LRP1 LRP2 LRP8 RHOH SLC35F5 SMO SMURF1 SMURF2 UTRN	4 interacting genes: ITGB1BP1 OGDH PDHX SLC2A4
Entrez ID		9270	1738
HPRD ID		06194	02006
Ensembl ID		ENSG00000119185	ENSG00000091140
Uniprot IDs		B4DQY5 O14713	A0A024R713 E9PEX6 P09622
PDB IDs		1K11 4DX8 4DX9 4JIF	1ZMC 1ZMD 1ZY8 2F5Z 3RNM 5J5Z 5NHG 6HG8 6I4P 6I4Q 6I4R 6I4S 6I4T 6I4U 6I4Z
Enriched GO Terms of Interacting Partners?
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