CRLF1 and CNTFR

Data Source:
HPRD (in vitro, in vivo)

		CRLF1	CNTFR
Description		cytokine receptor like factor 1	ciliary neurotrophic factor receptor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol External Side Of Plasma Membrane Receptor Complex CRLF-CLCF1 Complex	Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Cytokine Binding	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Signaling Receptor Binding Protein Binding Cytokine Binding
	Biological Process	Ureteric Bud Development Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Neuron Apoptotic Process Interleukin-27-mediated Signaling Pathway Negative Regulation Of Motor Neuron Apoptotic Process	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways		IL-6-type cytokine receptor ligand interactions Interleukin-27 signaling	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases		Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
GWAS		Blood protein levels ( 30072576) Dentures ( 31235808) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808)	Blood protein levels ( 30072576 29875488) Physiological traits ( 31902109)
Interacting Genes		2 interacting genes: CLCF1 CNTFR	9 interacting genes: APPBP2 CLCF1 CNTF CRLF1 IL6ST JPT2 KRTAP4-12 LIFR PLSCR1
Entrez ID		9244	1271
HPRD ID		09177	00348
Ensembl ID		ENSG00000006016	ENSG00000122756
Uniprot IDs		O75462	P26992
PDB IDs			1UC6
Enriched GO Terms of Interacting Partners?
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