LGI1 and SLC27A2

Data Source:
BioGRID (two hybrid, two hybrid)

		LGI1	SLC27A2
Description		leucine rich glioma inactivated 1	solute carrier family 27 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Synaptic Cleft Glutamatergic Synapse	Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding	Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transporter Activity ATP Binding Fatty Acid Transmembrane Transporter Activity Enzyme Binding Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Cholate-CoA Ligase Activity Phytanate-CoA Ligase Activity Pristanate-CoA Ligase Activity
	Biological Process	Nervous System Development Axon Guidance Positive Regulation Of Cell Growth Neuron Projection Development Positive Regulation Of Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Fatty Acid Alpha-oxidation Long-chain Fatty Acid Metabolic Process Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Very Long-chain Fatty Acid Catabolic Process Neutrophil Degranulation Long-chain Fatty Acid Import Into Cell Methyl-branched Fatty Acid Metabolic Process
Pathways		LGI-ADAM interactions	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Alpha-oxidation of phytanate Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Autosomal dominant temporal lobe epilepsy (ADTLE); Autosomal dominant partial epilepsy with auditory features (ADPEAF)
GWAS		Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Response to perphenazine in schizophrenia ( 29503163)	Blood metabolite ratios ( 24816252) Platelet count ( 32888494) Verbal declarative memory ( 25648963)
Interacting Genes		1 interacting genes: ADAM22	4 interacting genes: ABCD1 PEX5 UBC YWHAQ
Entrez ID		9211	11001
HPRD ID		05216	11935
Ensembl ID		ENSG00000108231	ENSG00000140284
Uniprot IDs		A0A0S2Z4S7 A0A0S2Z4X3 A0A0S2Z5G1 A0A1B0GUD3 O95970	O14975
PDB IDs		5Y2Z 5Y30 5Y31
Enriched GO Terms of Interacting Partners?
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