SLC27A2 and ABCD1

Data Source:
BioGRID (unspecified method)

		SLC27A2	ABCD1
Description		solute carrier family 27 member 2	ATP binding cassette subfamily D member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Specific Granule Membrane Extracellular Exosome	Cytoplasm Lysosomal Membrane Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transporter Activity ATP Binding Fatty Acid Transmembrane Transporter Activity Enzyme Binding Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Cholate-CoA Ligase Activity Phytanate-CoA Ligase Activity Pristanate-CoA Ligase Activity	Long-chain Fatty Acid Transporter Activity Protein Binding ATP Binding ABC-type Fatty-acyl-CoA Transporter Activity ATPase Activity Enzyme Binding ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity ADP Binding
	Biological Process	Fatty Acid Alpha-oxidation Long-chain Fatty Acid Metabolic Process Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Very Long-chain Fatty Acid Catabolic Process Neutrophil Degranulation Long-chain Fatty Acid Import Into Cell Methyl-branched Fatty Acid Metabolic Process	Regulation Of Oxidative Phosphorylation Fatty Acid Beta-oxidation Peroxisome Organization Long-chain Fatty Acid Import Into Peroxisome Fatty-acyl-CoA Transport Peroxisomal Membrane Transport Fatty Acid Elongation Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Catabolic Process Very Long-chain Fatty Acid Catabolic Process Myelin Maintenance Linoleic Acid Metabolic Process Regulation Of Mitochondrial Depolarization Transmembrane Transport Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Alpha-oxidation of phytanate Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import	ABC transporters in lipid homeostasis Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Defective ABCD1 causes ALD Class I peroxisomal membrane protein import
Drugs
Diseases			Adrenoleukodystrophy (ALD), including: Schilder-Addison Complex; Childhood cerebral adrenoleukodystrophy (CCER); adrenomyeloneuropathy (AMN)
GWAS		Blood metabolite ratios ( 24816252) Platelet count ( 32888494) Verbal declarative memory ( 25648963)
Interacting Genes		4 interacting genes: ABCD1 PEX5 UBC YWHAQ	5 interacting genes: ABCD2 ABCD3 PEX19 RPSA SLC27A2
Entrez ID		11001	215
HPRD ID		11935	02300
Ensembl ID		ENSG00000140284	ENSG00000101986
Uniprot IDs		O14975	P33897
PDB IDs
Enriched GO Terms of Interacting Partners?
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