BMP15 and KDM6A

Data Source:
BioGRID (two hybrid)

		BMP15	KDM6A
Description		bone morphogenetic protein 15	lysine demethylase 6A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Lumen	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Cytokine Activity Growth Factor Activity Type I Activin Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Chromatin DNA Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)
	Biological Process	Ovarian Follicle Development Female Gamete Generation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Granulosa Cell Development SMAD Protein Signal Transduction	Chromatin Remodeling Heart Development Regulation Of Gene Expression Histone H3-K4 Methylation Histone H3-K27 Demethylation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases		Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS
Interacting Genes		2 interacting genes: BMPR1B GDF9	11 interacting genes: GSC2 H3-4 H3C1 H3C14 MEOX2 MTDH NKX2-5 SMAD9 SRF TBX5 TLE1
Entrez ID		9210	7403
HPRD ID		02216	02131
Ensembl ID		ENSG00000130385	ENSG00000147050
Uniprot IDs		O95972	A0A087X0R0 A0A6Q8PFK0 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3 Q86TD1
PDB IDs			3AVR 3AVS 6FUK 6FUL
Enriched GO Terms of Interacting Partners?
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