CD247 and SLA

Data Source:
HPRD (in vivo)

		CD247	SLA
Description		CD247 molecule	Src like adaptor
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Endosome Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Dendritic Spine
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Tyrosine Kinase Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding
	Biological Process	Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Surface	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Cell Differentiation Innate Immune Response
Pathways			Negative regulation of FLT3
Drugs		Muromonab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 31672989 20383147 29293537 21779181)	Bone erosion in rheumatoid arthritis ( 28512992) Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Graves' disease ( 23612905) Multiple sclerosis ( 31604244) Temperament ( 22832960) Vitiligo ( 27723757 22561518)
Interacting Genes		38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	22 interacting genes: ABI2 BLK CBL CD247 EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR1 FLT3 GAB1 GSK3B LAT MYO15B PAFAH1B2 PTK6 QARS1 SYK UBE4A VAV1 ZAP70
Entrez ID		919	6503
HPRD ID		01729	03060
Ensembl ID		ENSG00000198821	ENSG00000155926
Uniprot IDs		P20963	Q13239
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR	2CUD
Enriched GO Terms of Interacting Partners?
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