SLA and UBE4A

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SLA	UBE4A
Description		Src like adaptor	ubiquitination factor E4A
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GO Annotations	Cellular Component	Endosome Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Dendritic Spine	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding	Protein Binding Ubiquitin-ubiquitin Ligase Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Cell Differentiation Innate Immune Response	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway
Pathways		Negative regulation of FLT3	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bone erosion in rheumatoid arthritis ( 28512992) Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Graves' disease ( 23612905) Multiple sclerosis ( 31604244) Temperament ( 22832960) Vitiligo ( 27723757 22561518)	Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)
Interacting Genes		22 interacting genes: ABI2 BLK CBL CD247 EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR1 FLT3 GAB1 GSK3B LAT MYO15B PAFAH1B2 PTK6 QARS1 SYK UBE4A VAV1 ZAP70	13 interacting genes: CASP6 EPHA2 GZMB IP6K1 MAVS PTTG1 RSAD2 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP
Entrez ID		6503	9354
HPRD ID		03060	06793
Ensembl ID		ENSG00000155926	ENSG00000110344
Uniprot IDs		Q13239	Q14139
PDB IDs		2CUD	1WGM
Enriched GO Terms of Interacting Partners?
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