WDR20 and USP46

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		WDR20	USP46
Description		WD repeat domain 20	ubiquitin specific peptidase 46
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GO Annotations	Cellular Component	Nucleoplasm	Nucleus Cytosol Glutamatergic Synapse
	Molecular Function	Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Deubiquitination	Behavioral Fear Response Ubiquitin-dependent Protein Catabolic Process Adult Feeding Behavior Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Synaptic Transmission, GABAergic Behavioral Response To Ethanol Righting Reflex Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Ub-specific processing proteases
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Biochemical measures ( 19260141) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Height ( 31562340) Platelet count ( 29403010) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)
Interacting Genes		5 interacting genes: LIG4 USP12 USP12P1 USP46 ZDHHC17	7 interacting genes: GRIA1 H2AC20 H2BC21 MAPK8IP2 UBA52 UBC WDR20
Entrez ID		91833	64854
HPRD ID		11679	07507
Ensembl ID		ENSG00000140153	ENSG00000109189
Uniprot IDs		A0A088AWN2 Q5JPH5 Q8TBZ3	P62068
PDB IDs		5K19 5K1C 6JLQ	5CVM 5CVN 5CVO 5L8H 6JLQ
Enriched GO Terms of Interacting Partners?
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