NEK9 and JDP2

Data Source:
BioGRID (proximity labelling technology)

		NEK9	JDP2
Description		NIMA related kinase 9	Jun dimerization protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Centrosome Cytosol	Chromatin Nucleus
	Molecular Function	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Histone Deacetylation Negative Regulation Of Fat Cell Differentiation
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs		Fostamatinib	Pseudoephedrine
Diseases
GWAS		Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Basal cell carcinoma ( 31174203) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 24076602) Obesity-related traits ( 23251661) Periodontal microbiota ( 22699663)
Interacting Genes		10 interacting genes: BICD2 CSN2 MBP NEK6 NEK7 NEK8 RAN SSRP1 SUPT16H TTN	22 interacting genes: ATF2 ATF4 CREB5 CREBBP DDIT3 EP300 GTF2H1 HDAC1 HDAC4 HDAC5 HDAC6 IRF2BP1 JUN JUNB JUND KAT2B MAPK14 MAPK8 MAPK9 PGR SNW1 TP53
Entrez ID		91754	122953
HPRD ID		11386	16360
Ensembl ID		ENSG00000119638	ENSG00000140044
Uniprot IDs		Q6PKF2 Q8TD19	A0A024R6D7 Q8WYK2
PDB IDs		3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?
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