LIN52 and NEK9

Data Source:
BioGRID (proximity labelling technology)

		LIN52	NEK9
Description		lin-52 DREAM MuvB core complex component	NIMA related kinase 9
Image
GO Annotations	Cellular Component	Nucleoplasm DRM Complex	Nucleus Centrosome Cytosol
	Molecular Function	Protein Binding	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Cell Cycle	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Division
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 28240269) Chronotype ( 30696823) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Waist-hip ratio ( 28552196)	Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		6 interacting genes: DYRK1A EPM2AIP1 MAGEA6 MYBL2 RBBP4 RBL2	10 interacting genes: BICD2 CSN2 MBP NEK6 NEK7 NEK8 RAN SSRP1 SUPT16H TTN
Entrez ID		91750	91754
HPRD ID		18708	11386
Ensembl ID		ENSG00000205659	ENSG00000119638
Uniprot IDs		B3KN83 Q52LA3	Q6PKF2 Q8TD19
PDB IDs		4YOO 6C48	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?
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