PRPF4 and U2AF1

Data Source:
BioGRID (two hybrid)

		PRPF4	U2AF1
Description		pre-mRNA processing factor 4	U2 small nuclear RNA auxiliary factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP U2-type Precatalytic Spliceosome Spliceosomal SnRNP Complex	Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck Catalytic Step 2 Spliceosome U2AF Complex
	Molecular Function	Protein Binding U6 SnRNA Binding U4 SnRNA Binding	RNA Binding Protein Binding Pre-mRNA 3'-splice Site Binding Metal Ion Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA 3'-end Processing
Pathways		mRNA Splicing - Major Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		White matter growth ( 29682794)	Blood and toenail selenium levels ( 25343990)
Interacting Genes		9 interacting genes: APP ATP5MF CLK1 GPKOW PPIH SRSF1 TGFBR1 U2AF1 WBP4	51 interacting genes: AP1B1 AP2B1 CARNMT1 CHERP CIR1 CLK2 DHX38 EFHC2 EPB41 FRA10AC1 HINFP HNRNPK HNRNPM IL7R JMJD6 KRT1 KRT75 MAP1B MEOX2 MFAP1 MLH1 NDN NKAP NXF1 PABPC1 PRPF19 PRPF38A PRPF4 PRPF40A PTEN RBM10 RNPS1 RP9 SF3A3 SF3B2 SNRNP35 SNRPD1 SRPK1 SRRM4 SRSF1 SRSF2 SRSF3 SUV39H1 TOE1 TRA2B U2AF2 VEGFA ZCCHC10 ZNF417 ZRANB2 ZRSR2
Entrez ID		9128	7307
HPRD ID		08479	01871
Ensembl ID		ENSG00000136875	ENSG00000160201
Uniprot IDs		O43172 Q5T1M7	P0DN76 Q01081 Q7Z780
PDB IDs		1MZW 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	1JMT
Enriched GO Terms of Interacting Partners?
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