AIP and TNNI3K

Data Source:
HPRD (two hybrid)

		AIP	TNNI3K
Description		aryl hydrocarbon receptor interacting protein	TNNI3 interacting kinase
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Aryl Hydrocarbon Receptor Complex	Nucleus Cytoplasm
	Molecular Function	Transcription Coactivator Activity Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Transcription Factor Binding Aryl Hydrocarbon Receptor Binding GAF Domain Binding Unfolded Protein Binding	Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Troponin I Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization Protein Targeting To Mitochondrion Xenobiotic Metabolic Process Regulation Of Protein Kinase A Signaling Protein Maturation By Protein Folding Interleukin-12-mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity	Regulation Of Heart Rate Protein Phosphorylation Regulation Of Cardiac Muscle Contraction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cardiac Conduction
Pathways		Aryl hydrocarbon receptor signalling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Urate levels ( 31578528)	Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 26426971 23669352 28892062 20935630 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005 26604143) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965 25231870) Mental health study participation (completed survey) ( 31263887) Obesity ( 23563607) Parental longevity (combined parental age at death) ( 29227965) Pubertal anthropometrics ( 23449627) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		18 interacting genes: AHR ARNT CLEC7A CSNK2A1 EGFR ERBB2 GNA13 GNAQ HSP90AA1 HTR6 IKBKG IRF7 PDE4A PPARA PTGES3 STIP1 TNNI3K TOMM20	8 interacting genes: ACTA1 ACTC1 AIP FABP3 FBXO4 HADHB MYBPC3 TNNI3
Entrez ID		9049	51086
HPRD ID		10408	18208
Ensembl ID		ENSG00000110711	ENSG00000116783
Uniprot IDs		G9I2H4 O00170	Q59H18
PDB IDs		2LKN 4AIF 4APO	4YFF 4YFI 6B5J
Enriched GO Terms of Interacting Partners?
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