CCNT1 and NCOA2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		CCNT1	NCOA2
Description		cyclin T1	nuclear receptor coactivator 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex P-TEFb Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body Protein-containing Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding Aryl Hydrocarbon Receptor Binding Protein Domain Specific Binding Nuclear Receptor Coactivator Activity Nuclear Hormone Receptor Binding Protein Dimerization Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Cell Cycle Viral Process Positive Regulation Of DNA-templated Transcription, Elongation SnRNA Transcription By RNA Polymerase II Positive Regulation By Host Of Viral Transcription Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Cell Division Negative Regulation Of MRNA Polyadenylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Glucose Metabolic Process Bile Acid And Bile Salt Transport Regulation Of Lipid Metabolic Process Response To Progesterone Cellular Response To Hormone Stimulus Circadian Regulation Of Gene Expression Locomotor Rhythm Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Thyroglobulin Triiodothyronine
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Estrogen-dependent gene expression
Drugs			Diethylstilbestrol Genistein Metribolone 17-METHYL-17-ALPHA-DIHYDROEQUILENIN 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol TO-901317 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL 2-chloro-5-nitro-N-phenylbenzamide dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL Tributyltin 2-(4-hydroxyphenyl)benzo[b]thiophen-6-ol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353)	Apolipoprotein A1 levels ( 32203549) Cardiac Troponin-T levels ( 23247143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549 28334899) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Multiple sclerosis ( 24076602) Non-small cell lung cancer ( 23144319) Plateletcrit ( 32888494) QT interval ( 24952745) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 29403010) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subclinical trait of interstitial lung disease (basilar peel-core ratio of high attentuation areas on CT scan) ( 28521775) Systemic lupus erythematosus ( 33536424)
Interacting Genes		26 interacting genes: AFF4 AHR BRD4 CDK9 CEBPB ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MDFIC MYC NCOA2 NUFIP1 PML POLR2A PRKCI PURA RN7SK SKP2 SUPT5H	65 interacting genes: ACTN2 AHR ANKRD11 AR ARNT BRCA1 CARM1 CCND3 CCNT1 CDK4 CREBBP CTNNB1 DDX17 DDX5 DLX2 DLX5 EID1 EP300 ESR1 ESR2 ESRRB ETV1 FLII FOS GMEB1 H3-4 H4-16 HIF1A HNF4A JUN KIF5A KIF5B KIF5C MAGEA11 MEF2C NKX2-1 NR1I2 NR2F1 NR3C1 NR4A1 OPN1LW PIAS3 PML PPARA PPARD PPARG PPFIA1 PPFIA4 PRMT1 PSMB9 RARA RORA RXRA SLC30A9 SMARCE1 SRCAP STAT6 SUMO1 TAF9 THRA THRB TP53 TXNRD2 VDR YWHAH
Entrez ID		904	10499
HPRD ID		03938	09066
Ensembl ID		ENSG00000129315	ENSG00000140396
Uniprot IDs		A8K4M5 O60563	B4DPW8 Q15596
PDB IDs		2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH	1GWQ 1GWR 1M2Z 1MV9 1MVC 1MZN 1P93 1T63 1T65 1UHL 1YOK 1ZDT 1ZDU 1ZKY 2AO6 2B1V 2B1Z 2B23 2FAI 2G44 2G5O 2LDC 2P15 2P1T 2P1U 2P1V 2Q7J 2Q7L 2YJD 2ZXZ 2ZY0 3A9E 3CLD 3DZU 3DZY 3E00 3E7C 3E94 3ERD 3FUG 3GN8 3K22 3K23 3KWY 3KYT 3L0E 3L0J 3L0L 3O1D 3O1E 3OAP 3OZJ 3PCU 3PLZ 3Q95 3R5M 3UP0 3UP3 4CSJ 4DOS 4E2J 4FHH 4FHI 4IA1 4IA2 4IA3 4IA7 4IQR 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4K4J 4K6I 4M8E 4M8H 4NIE 4NQA 4OC7 4P6W 4P6X 4PLD 4PLE 4POH 4POJ 4PP3 4PP5 4PP6 4PPP 4PPS 4PXM 4Q0A 4Q13 4QE6 4QE8 4RFW 4RMC 4RMD 4RME 4RUO 4UDC 4UDD 4WG0 4ZN7 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW 4ZO1 4ZSH 5APH 5APJ 5DI7 5DID 5DIE 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4 5DLR 5DMC 5DMF 5DP0 5DRJ 5DRM 5DTV 5DU5 5DUE 5DUG 5DUH 5DVS 5DVV 5DWE 5DWG 5DWI 5DWJ 5DX3 5DXB 5DXE 5DXG 5DXK 5DXM 5DXP 5DXQ 5DXR 5DY8 5DYB 5DYD 5DZ0 5DZ1 5DZ3 5DZH 5DZI 5E0W 5E0X 5E14 5E15 5E19 5E1C 5EC9 5EGV 5EHJ 5EI1 5EIT 5G3J 5G42 5G43 5G44 5G45 5G46 5G5W 5H1E 5HYR 5I4V 5IAW 5ICK 5KCC 5KCD 5KCE 5KCF 5KCT 5KCU 5KCW 5KD9 5KR9 5KRA 5KRC 5KRF 5KRH 5KRI 5KRJ 5KRK 5KRL 5KRM 5KRO 5L11 5LGA 5LYQ 5MK4 5NFP 5NFT 5NI5 5NI7 5NI8 5NIB 5Q17 5SYZ 5T1Z 5TLD 5TLF 5TLG 5TLL 5TLM 5TLO 5TLP 5TLT 5TLU 5TLV 5TLX 5TLY 5TM1 5TM2 5TM3 5TM4 5TM5 5TM6 5TM7 5TM8 5TM9 5TML 5TMM 5TMO 5TMQ 5TMR 5TMS 5TMT 5TMU 5TMV 5TMW 5TMZ 5TN1 5TN3 5TN4 5TN5 5TN6 5TN7 5TN8 5U2D 5UAN 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5WGQ 5WZX 5XPL 5Y1J 5Y49 5YP5 5YXB 5YXD 5YXJ 5YXL 5Z12 6CZN 6D0F 6EL6 6EL7 6EL9 6ESN 6KKB 6KKE 6KNU 6KNV 6KNW 6LIT 6OQX 6OQY 6OR1 6R7A 6R7J 6R7K 6SJM 6STI 6VIF 7A77 7A78 7A79
Enriched GO Terms of Interacting Partners?
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