TICRR and TOPBP1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology)

		TICRR	TOPBP1
Description		TOPBP1 interacting checkpoint and replication regulator	DNA topoisomerase II binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Protein Binding	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	DNA Replication DNA Repair Mitotic Cell Cycle Checkpoint Mitotic G2 DNA Damage Checkpoint Response To Ionizing Radiation Regulation Of DNA-dependent DNA Replication Initiation Mitotic DNA Replication Checkpoint	DNA Metabolic Process DNA Replication DNA Replication Initiation DNA Repair Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Regulation Of Signal Transduction By P53 Class Mediator
Pathways			HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Resting oxygen saturation in chronic osbtructive pulmonary disease (pulse oxymetry) ( 24825563) Type 2 diabetes ( 31049640)	Iron status biomarkers ( 19084217)
Interacting Genes		2 interacting genes: APP TOPBP1	32 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17
Entrez ID		90381	11073
HPRD ID		11357	09678
Ensembl ID		ENSG00000140534	ENSG00000163781
Uniprot IDs		Q7Z2Z1	A0AV47 A7E2X7 Q05BV8 Q92547
PDB IDs			1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM
Enriched GO Terms of Interacting Partners?
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