F2RL3 and F2RL2

Data Source:
HPRD (in vivo)

		F2RL3	F2RL2
Description		F2R like thrombin or trypsin receptor 3	coagulation factor II thrombin receptor like 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Protein-containing Complex
	Molecular Function	G Protein-coupled Receptor Activity Thrombin-activated Receptor Activity	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding Thrombin-activated Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Blood Coagulation Response To Wounding Platelet Activation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Platelet Dense Granule Organization Thrombin-activated Receptor Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Blood Coagulation Response To Wounding Platelet Activation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Thrombin-activated Receptor Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)	Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
Drugs		Thrombin
Diseases
GWAS		Metabolite levels ( 23823483)	Mean platelet volume ( 28031487) Phenylephrine infusion rate during anesthesia ( 31455332)
Interacting Genes		2 interacting genes: F2 F2RL2	8 interacting genes: CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3
Entrez ID		9002	2151
HPRD ID		04148	03561
Ensembl ID		ENSG00000127533	ENSG00000164220
Uniprot IDs		Q96RI0	O00254
PDB IDs		2ZPK 3QDZ
Enriched GO Terms of Interacting Partners?
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