HPS4 and HPS1

Data Source:
HPRD (in vivo)

		HPS4	HPS1
Description		HPS4 biogenesis of lysosomal organelles complex 3 subunit 2	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane BLOC-3 Complex Cytoplasmic Vesicle Melanosome Platelet Dense Granule	Cytoplasm Lysosome Cytosol BLOC-3 Complex Cytoplasmic Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity Protein Dimerization Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Protein Targeting Lysosome Organization Blood Coagulation Hemostasis Vesicle-mediated Transport Melanocyte Differentiation Positive Regulation Of Eye Pigmentation Regulation Of Catalytic Activity Protein Stabilization Melanosome Assembly Positive Regulation Of Protein Targeting To Mitochondrion	Lysosome Organization Visual Perception Vesicle-mediated Transport Regulation Of Catalytic Activity Response To Stimulus Melanosome Assembly
Pathways		RAB GEFs exchange GTP for GDP on RABs	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Hermansky-Pudlak syndrome (HPS)	Hermansky-Pudlak syndrome (HPS)
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Ischemic stroke ( 26089329)	Bitter non-alcoholic beverage consumption ( 31046077) Metabolite levels ( 23823483) Obesity-related traits ( 23251661)
Interacting Genes		2 interacting genes: HPS1 RAC1	2 interacting genes: HPS4 PSEN2
Entrez ID		89781	3257
HPRD ID		05983	05403
Ensembl ID		ENSG00000100099	ENSG00000107521
Uniprot IDs		A8K2E6 Q6P1K3 Q9NQG7	A0A0S2Z3U1 A0A0S2Z3U9 Q658M9 Q92902
PDB IDs
Enriched GO Terms of Interacting Partners?
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