HPS1 and HPS4

Data Source:
HPRD (in vivo)

		HPS1	HPS4
Description		HPS1 biogenesis of lysosomal organelles complex 3 subunit 1	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol BLOC-3 Complex Cytoplasmic Vesicle	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane BLOC-3 Complex Cytoplasmic Vesicle Melanosome Platelet Dense Granule
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Dimerization Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity Protein Dimerization Activity
	Biological Process	Lysosome Organization Visual Perception Vesicle-mediated Transport Regulation Of Catalytic Activity Response To Stimulus Melanosome Assembly	Protein Targeting Lysosome Organization Blood Coagulation Hemostasis Vesicle-mediated Transport Melanocyte Differentiation Positive Regulation Of Eye Pigmentation Regulation Of Catalytic Activity Protein Stabilization Melanosome Assembly Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		RAB GEFs exchange GTP for GDP on RABs	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Hermansky-Pudlak syndrome (HPS)	Hermansky-Pudlak syndrome (HPS)
GWAS		Bitter non-alcoholic beverage consumption ( 31046077) Metabolite levels ( 23823483) Obesity-related traits ( 23251661)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Ischemic stroke ( 26089329)
Interacting Genes		2 interacting genes: HPS4 PSEN2	2 interacting genes: HPS1 RAC1
Entrez ID		3257	89781
HPRD ID		05403	05983
Ensembl ID		ENSG00000107521	ENSG00000100099
Uniprot IDs		A0A0S2Z3U1 A0A0S2Z3U9 Q658M9 Q92902	A8K2E6 Q6P1K3 Q9NQG7
PDB IDs
Enriched GO Terms of Interacting Partners?
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