MBD2 and GATAD2B

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MBD2	GATAD2B
Description		methyl-CpG binding domain protein 2	GATA zinc finger domain containing 2B
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Heterochromatin Nucleus Nucleoplasm Cytosol Protein-containing Complex	Chromatin Nucleoplasm NuRD Complex Nuclear Speck Protein-containing Complex
	Molecular Function	Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding C2H2 Zinc Finger Domain Binding	Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Assembly DNA Methylation-dependent Heterochromatin Assembly Heart Development Aging Response To Mechanical Stimulus Positive Regulation Of Wnt Signaling Pathway Response To Nutrient Levels Response To Estradiol Cellular Protein-containing Complex Assembly Positive Regulation Of Chromatin Binding Regulation Of Cell Population Proliferation Maternal Behavior ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Negative Regulation Of Transcription, DNA-templated Embryonic Organ Development Cellular Response To Organic Cyclic Compound	Negative Regulation Of Transcription By RNA Polymerase II ATP-dependent Chromatin Remodeling
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Body size at age 10 ( 32376654) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Nickel levels ( 26025379) Periodontitis (Mean PAL) ( 24024966) Prostate cancer ( 29892016) Psoriasis ( 23143594)	Age at first birth ( 27798627) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General cognitive ability ( 29844566) Height ( 31562340) Lentiform nucleus volume ( 22903471) Number of children ever born ( 27798627) Raw vegetable consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		16 interacting genes: CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 PURB RBBP4 SIN3A TBP	29 interacting genes: CALCOCO2 CDKN2D CEP70 ERCC6 FHL2 GOLGA2 GPSM3 H2AC20 H2BC21 H3C1 H4C1 KAT2B MBD2 MBD3 MTNR1A NGB NME7 NOXA1 PRKAB2 RBPMS RPGRIP1 SBK3 SMAD2 SUMO2 TEX11 TRAF1 TRIM27 USHBP1 ZGPAT
Entrez ID		8932	57459
HPRD ID		04647	15094
Ensembl ID		ENSG00000134046	ENSG00000143614
Uniprot IDs		A0A024R2B8 Q9UBB5	Q8WXI9
PDB IDs		2L2L 6C1A 6C1T 6C1U 6C1V 6C2F 6CNP 6CNQ
Enriched GO Terms of Interacting Partners?
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