FOXH1 and RECQL4

Data Source:
BioGRID (pull down, two hybrid)

		FOXH1	RECQL4
Description		forkhead box H1	RecQ like helicase 4
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Activin Responsive Factor Complex	Chromosome, Telomeric Region Nucleus Chromosome Cytoplasm Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding	Bubble DNA Binding Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Oxidized Purine DNA Binding Annealing Helicase Activity 3'-5' DNA Helicase Activity Telomeric D-loop Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Strand Renaturation DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination Multicellular Organism Development DNA Duplex Unwinding Telomeric D-loop Disassembly
Pathways		Signaling by NODAL Signaling by Activin
Drugs
Diseases			RAPADILINO syndrome Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Blood metabolite levels ( 26401656) Educational attainment ( 25201988) General cognitive ability ( 29844566)	Age at first birth ( 27798627) Educational attainment ( 25201988) General cognitive ability ( 29844566)
Interacting Genes		67 interacting genes: AOC1 ARID5A ATP23 ATXN1L BATF2 C10orf55 C11orf1 C19orf54 CEACAM6 CRX CRYBA1 CYSRT1 DAZAP2 DRAP1 FAM168B FAM83A FOXD2 FOXG1 HDHD3 HEY1 HLX HOXA1 HSF4 KLHL26 KRTAP11-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP7-1 LASP1 MAGED1 MGAT5B MSX2 NKX2-5 NOTO OXER1 PLA2G10 PNMA5 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 RBM46 RBPMS2 RNF144B SERGEF SMAD2 SMAD3 SMAD4 SOX14 SOX4 TEKT5 TFG TLX3 TSC1 UBAP2 UFSP1 ZC3H10 ZIC1 ZNF34 ZNF503	7 interacting genes: ACD EP300 MCM10 POT1 PRSS23 TERF1 TERF2IP
Entrez ID		8928	9401
HPRD ID		04689	04805
Ensembl ID		ENSG00000160973	ENSG00000160957
Uniprot IDs		O75593	O94761
PDB IDs		5XOC	2KMU 5LST
Enriched GO Terms of Interacting Partners?
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