RECQL4

Description		RecQ like helicase 4
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Chromosome Cytoplasm Membrane
	Molecular Function	Bubble DNA Binding Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Oxidized Purine DNA Binding Annealing Helicase Activity 3'-5' DNA Helicase Activity Telomeric D-loop Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Strand Renaturation DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination Multicellular Organism Development DNA Duplex Unwinding Telomeric D-loop Disassembly
Pathways
Drugs
Diseases		RAPADILINO syndrome Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Age at first birth ( 27798627) Educational attainment ( 25201988) General cognitive ability ( 29844566)
Novel Interacting Genes		1 novel interacting genes: FOXH1
Interacting Genes		7 interacting genes: ACD EP300 MCM10 POT1 PRSS23 TERF1 TERF2IP
Entrez ID		9401
HPRD ID		04805
Ensembl ID		ENSG00000160957
Uniprot IDs		O94761
PDB IDs		2KMU 5LST
Enriched GO Terms of Interacting Partners?
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