ASAP2 and PACSIN3

Data Source:
HPRD (two hybrid)

		ASAP2	PACSIN3
Description		ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	protein kinase C and casein kinase substrate in neurons 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Golgi Cisterna Membrane	Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity Identical Protein Binding
	Biological Process	Positive Regulation Of GTPase Activity	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation
Pathways			Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease ( 30804561) Pulse pressure ( 27841878 30578418) Urate levels ( 31578528)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		14 interacting genes: APC ARF1 ARF5 ARF6 BIN1 GRB2 ITSN1 PACSIN3 PTK2B PXN RAN REPS2 SH3KBP1 THSD7A	23 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 ATXN7L2 CLNK DNM1 ITSN1 KRTAP12-2 LGALS13 PACSIN1 PACSIN2 PAK2 RAF1 SMARCD1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TNPO2 TRPV4 WASL
Entrez ID		8853	29763
HPRD ID		04820	05937
Ensembl ID		ENSG00000151693	ENSG00000165912
Uniprot IDs		O43150	Q9UKS6
PDB IDs
Enriched GO Terms of Interacting Partners?
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