CCK and CCKBR

Data Source:
HPRD (in vivo, in vitro)

		CCK	CCKBR
Description		cholecystokinin	cholecystokinin B receptor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Axon Dendrite Axon Initial Segment Terminal Bouton Axon Hillock Perikaryon	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Peptide Hormone Receptor Binding	Cholecystokinin Receptor Activity Protein Binding Gastrin Receptor Activity Peptide Hormone Binding Type B Gastrin/cholecystokinin Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Neuron Migration Release Of Cytochrome C From Mitochondria Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Digestion Memory Positive Regulation Of Cell Population Proliferation Visual Learning Positive Regulation Of Glutamate Secretion Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Appetite Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Eating Behavior Positive Regulation Of Sensory Perception Of Pain Negative Regulation Of Behavioral Fear Response Positive Regulation Of Behavioral Fear Response	Gastric Acid Secretion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Cholecystokinin Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity PH Reduction Digestive Tract Development Gland Development
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Camostat	Pentagastrin Cholecystokinin
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 24348519 28892062 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (SNP x SNP interaction) ( 22344221) Body size at age 10 ( 32376654) Night sleep phenotypes ( 27126917)	Diastolic blood pressure ( 30224653) Early spontaneous preterm birth ( 31194736) Gastroesophageal reflux disease ( 31527586) Malaria ( 31844061)
Interacting Genes		7 interacting genes: CCKAR CCKBR CPE ENPEP MEP1A MEP1B UBQLN2	10 interacting genes: ADRB2 ATP13A2 CCK CCKAR CCR4 DRD2 NTM PPP1R9B PTPN11 SLCO1B3
Entrez ID		885	887
HPRD ID		00321	00323
Ensembl ID		ENSG00000187094	ENSG00000110148
Uniprot IDs		P06307 Q6FG82	E9PIC8 P32239
PDB IDs			1L4T
Enriched GO Terms of Interacting Partners?
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