DLK1 and GAS1

Data Source:
HPRD (two hybrid)

		DLK1	GAS1
Description		delta like non-canonical Notch ligand 1	growth arrest specific 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Membrane Anchored Component Of Plasma Membrane
	Molecular Function	Molecular_function Calcium Ion Binding Protein Binding	Protein Binding
	Biological Process	Cell Differentiation Negative Regulation Of Notch Signaling Pathway	Cell Cycle Arrest Regulation Of Smoothened Signaling Pathway Negative Regulation Of Protein Processing Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Mitotic Cell Cycle Developmental Growth Regulation Of ER To Golgi Vesicle-mediated Transport
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus	Ligand-receptor interactions Activation of SMO
Drugs
Diseases
GWAS		Adult body size ( 32376654) Birth weight ( 31043758) Blood protein levels ( 29875488) Body size at age 10 ( 32376654) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Height ( 31562340) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Platelet count ( 22139419 29403010) Refractive error ( 32231278) Type 1 diabetes ( 19966805) Type 2 diabetes ( 32499647)	Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Heel bone mineral density ( 30598549) Insulin resistance/response ( 21901158) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		3 interacting genes: GAS1 GRN ZDHHC17	4 interacting genes: BIRC2 DLK1 ERRFI1 SHH
Entrez ID		8788	2619
HPRD ID		01446	00747
Ensembl ID		ENSG00000185559	ENSG00000180447
Uniprot IDs		A0A024R6L1 A8K019 P80370	P54826
PDB IDs
Enriched GO Terms of Interacting Partners?
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